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Institute of Particle Technology
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  1. Friedrich-Alexander-Universität
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  1. Friedrich-Alexander-Universität
  2. Faculty of Engineering
  3. Department Chemical and Biological Engineering

Institute of Particle Technology

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Proteins at Interfaces

In page navigation: Research
  • Research Groups
    • Interface Engineering and Particle Technology (Peukert Group)
      • Additive Manufacturing
        • Liquid Phase Production of Functional Polymer Particles (CRC 814 Project A1)
        • Modification and Functionalization of Powders in Gas Phase (SFB 814 Project A2)
        • Quality assurance system for powders used in selective laser beam melting of polymers (SFB 814 Transfer Project T1)
      • Advanced Colloid Characterization
        • Multidimensional analysis of nanoparticulate structures using analytical ultracentrifugation with integrated multiwavelength detection
        • Development of multidimensional analysis of particulate systems using analytical centrifugation
        • Multiwavelength emission characterization of nanoparticles by means of a novel analytical ultracentrifuge
      • Characterization of Carbon Dots
      • Comminution
      • Surfaces and Interfaces
        • Proteins at Interfaces
        • Emulsions
        • Surface Functionalization, Degradation, and Corrosion
      • Synthesis, Surface Modification and In Situ Analysis
        • In situ monitoring of particle formation
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Proteins at Interfaces

Contact:

Guckeisen, Tobias

Short description:

In situ investigations of structural changes of biomolecules at the interface and under mechanical stress

Participating project in Priority Programme (SPP) 1934 DispBiotech

Proteins structure, interfacial properties, and dynamical behavior are of relevance in a wide range of applications. For instance, in the food industry which proteins are commonly used as emulsifiers, their long term stability is of concern. In pharmaceutical industries, the degradation of biomolecules during processing and storage is a frequent problem. In this project, we explore the stability and resilience of biomolecules, like proteins, at the interface and in bulk solution under various chemical, interfacial and mechanical stresses.

To shade light on the protein structure and dynamic at the interface we utilize SFG (sum frequency generation) spectroscopy, which enables us to gain information about molecular composition, orientation and charge of proteins the surfaces and interfaces. SFG works by overlapping a fixed visible (800 nm) and a tunable IR beam at the interface to generate an SFG beam, whose frequency is the sum of both incoming beams. By changing the polarization of the beams, we can selectively probe chirality of the interfacial molecules. Chiral SFG is applied to investigate secondary structures of proteins at the interface.

Recent publications:

  • Guckeisen, T., Hosseinpour, S., & Peukert, W. (2019). Isoelectric points of proteins at the air/liquid interface and in solution. Langmuir, 35(14), 5004-5012. https://dx.doi.org/10.1021/acs.langmuir.9b00311
Friedrich-Alexander-Universität Erlangen-Nürnberg
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik

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91058 Erlangen
Germany
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